RxSkin Fountain Monograph
Tretinoin 0.03%, Bisabolol 0.1%, Tetrahexyldecyl Ascorbate 2%, Vitamin E Acetate 1%, Aloe Vera 200:1 Extract 2%, Ferulic Acid 0.05%
Important Safety Information
RxSkin Fountain is intended for use in individuals over the age of 18 and is not suitable for children. This medication should not be used during pregnancy, if planning to become pregnant, or while breastfeeding. The information provided does not replace the advice of a healthcare provider and should be discussed with a medical professional before initiating treatment.
What is Fountain Used For?
RxSkin Fountain is indicated for the topical treatment of fine lines, wrinkles, and other visible signs of skin aging. This formulation combines a prescription-strength retinoid with anti-inflammatory, antioxidant, and hydrating components to improve the appearance of aging skin.
How Does Fountain Work?
RxSkin Fountain combines multiple active ingredients to target signs of aging through complementary mechanisms. Tretinoin, a retinoid, works by stimulating cell turnover and promoting the shedding of old skin cells while encouraging the growth of new ones. This helps improve skin texture, reduce fine lines, and even out skin tone. Tetrahexyldecyl Ascorbate (Vitamin C derivative) acts as a powerful antioxidant, protecting the skin from free radical damage and supporting collagen synthesis. Bisabolol and Aloe Vera provide anti-inflammatory and soothing effects, while Vitamin E Acetate and Ferulic Acid offer additional antioxidant protection and hydration to enhance skin barrier function.
Pharmacology and Mechanism of Action
Tretinoin (0.03%) is a retinoid that modulates epithelial cell growth and differentiation. It binds to specific nuclear retinoic acid receptors (RARs), particularly RAR-γ in the skin, leading to changes in gene transcription. This enhances epidermal cell turnover, promoting the exfoliation of keratinized skin cells while encouraging the production of new cells. Additionally, tretinoin stimulates fibroblast activity, promoting collagen synthesis and reducing collagen degradation by inhibiting matrix metalloproteinases (MMPs), enzymes responsible for breaking down extracellular matrix components.
Tetrahexyldecyl Ascorbate (2%), a lipid-soluble derivative of Vitamin C, penetrates deeper into the dermis than traditional ascorbic acid. It supports collagen production by acting as a cofactor for prolyl hydroxylase and lysyl hydroxylase, enzymes crucial for collagen stabilization and cross-linking. It also acts as an antioxidant, neutralizing free radicals that contribute to photoaging and environmental damage.
Bisabolol (0.1%), a natural anti-inflammatory compound derived from chamomile, inhibits the release of pro-inflammatory cytokines such as IL-1 and TNF-α, which helps soothe irritated skin. It also possesses antimicrobial properties, supporting the skin's barrier function.
Vitamin E Acetate (1%) functions as a lipid-based antioxidant, protecting cell membranes from oxidative damage. Upon topical application, it is gradually hydrolyzed by skin esterases to yield free tocopherol, the biologically active form of vitamin E. Tocopherol acts by scavenging free radicals and reactive oxygen species, which are generated by ultraviolet radiation and environmental stressors, thereby mitigating oxidative damage to skin cells and lipids. It also plays a supportive role in enhancing skin hydration by improving the water-binding capacity of the stratum corneum, indirectly aiding in the restoration of skin suppleness and reducing the appearance of fine lines and wrinkles.
Aloe Vera 200:1 Extract (2%) exerts multiple pharmacodynamic actions that support skin health and repair, particularly in formulations designed for anti-aging. The polysaccharides in aloe vera form a protective, moisturizing barrier on the skin, enhancing water retention in the stratum corneum and improving skin hydration. Aloe vera also possesses notable anti-inflammatory properties, mediated in part by inhibition of cyclooxygenase (COX) and subsequent prostaglandin E2 (PGE2) synthesis. This helps reduce erythema, edema, and irritation in inflamed or sensitive skin. The antioxidative effects of aloe vera assist in neutralizing reactive oxygen species and protecting against oxidative stress, a key contributor to photoaging.
Ferulic Acid (0.05%) exerts its effects primarily through its potent free radical scavenging ability. It neutralizes reactive oxygen species, including hydroxyl radicals, superoxide, and nitric oxide, which are known to accelerate skin aging by damaging cellular structures, proteins, and DNA. This potent plant-based antioxidant also stabilizes Vitamins C and E, enhancing their effectiveness in the formulation. Additionally, Ferulic Acid’s anti-inflammatory effects are demonstrated by modulating signaling pathways involved in skin irritation and inflammatory cytokine production.
Dosage Form
RxSkin Fountain is formulated as an anhydrous cream. Each pump dispenses 0.25 mL, intended for application as a thin, even layer massaged into the affected skin areas.
How to Use Fountain
Use 2 pumps to apply a thin layer of the cream to the affected areas and gently massage upwards into the skin. The product is to be used once daily at bedtime or as directed by a healthcare provider. Prior to application, cleanse the skin with a gentle cleanser and pat dry. Allow the skin to dry completely for 5 to 10 minutes before applying the cream. Hands should be washed both before and after application.
Do not use Increased amounts of Fountain to make up for a dose that you have missed. Continue with your usual dosing schedule
To achieve optimal results, avoid washing the face or applying other skincare products, including makeup, for at least one hour following application. Avoid contact with the eyes, mucous membranes, and broken or irritated skin. In the event of accidental contact, rinse thoroughly with water.
A moisturizing sunscreen with SPF 30 or higher should be used during the day to minimize skin irritation and enhance the treatment's benefits.
Fountain may cause dryness, redness, or peeling during the initial weeks of use. To ease into treatment and minimize irritation, consider applying Fountain every third night for the first 1–2 weeks. If the irritation subsides, the frequency of application may be increased to every other night during weeks 3 and 4. After approximately 4 weeks, consider a nightly application for best results.
When to Expect Results
Improvements may take several weeks to become noticeable. Initial use, typically within the first 4 to 6 weeks, may cause temporary skin irritation, redness, and dryness. The formulation contains hydrating and soothing agents designed to reduce these effects.
By weeks 8 to 12, users may observe improvements in skin elasticity, texture, and tone, with a reduction in wrinkles and fine lines. Continued use in combination with sun protection is recommended for sustained benefits.
Who Should not Use Fountain?
RxSkin Fountain is contraindicated in individuals with:
Warnings and Precautions
RxSkin Fountain should not be used during pregnancy, if planning to become pregnant, or while breastfeeding. Individuals with known hypersensitivity or allergic reactions to any components of this product should avoid use and consult a healthcare provider.
In rare cases, severe reactions may occur. Medical attention should be sought immediately if signs of a serious allergic reaction develop, including rash, hives, severe itching, swelling (especially of the face, lips, tongue, or throat), difficulty breathing, or chest tightness.
Severe skin reactions, including persistent irritation, redness, blistering, or peeling, require prompt medical evaluation.
Patients should avoid using other retinol products or topical agents containing duplicated ingredients without consulting a healthcare provider. Overuse or excessive application may lead to severe skin irritation.
Sun exposure and tanning beds should be avoided. RxSkin Fountain should not be applied to sunburned skin; treatment may resume once the sunburn subsides. This product is for external use only and must be kept out of reach of children.
Possible Side Effects & What to Watch For
When first starting treatment, your skin may go through an “adjustment period.” This is normal and often temporary. Most side effects are mild to moderate and tend to improve as your skin builds tolerance to the treatment. If these effects persist beyond 2 to 4 weeks, or become uncomfortable, please consult your healthcare provider.
Common side effects (>10%) include:
Less common side effects (<10%) include:
Overdose Management
Topical overdose may lead to excessive irritation, peeling, and discomfort. If severe skin reactions occur, discontinue use and consult a healthcare provider. Systemic toxicity from topical use is unlikely but may require medical attention if large quantities are accidentally ingested.
Special Populations
Drug Interactions and Medical History
Patients should inform their healthcare provider of all current medications, including prescription, over-the-counter, and homeopathic treatments. Particular attention should be given to medications containing tretinoin or other active ingredients present in RxSkin Fountain. Medication regimens should not be started, stopped, or altered without medical guidance.
A history of skin conditions such as eczema, psoriasis, skin cancer, or dermatitis should be disclosed to assess the appropriateness of this medication. Known hypersensitivity to any ingredients must also be reported to the healthcare provider.
There have been no formal studies evaluating the interaction of Fountain with other drugs.
Storage
Store RxSkin Fountain at room temperature (20-25°C / 68-77°F). Protect from direct sunlight. Keep out of reach of children and pets. A slight change in the color of your product can be expected over time. This can appear as a yellowish tinge, which is normal and does not affect the product’s safety or effectiveness. Tretinoin itself is naturally yellow, but it is often formulated to appear more white or neutral for cosmetic elegance. With time and even in correct storage conditions, the product may gradually return to its natural color. Do not use this product past the labelled expiry date.
For External Use Only.
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